3ETO

2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)

Summary for 3ETO

• Entry DOI: 10.2210/pdb3eto/pdb
• Descriptor: Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: alpha-beta sandwich, hd domain, lnr repeat, calcium-binding, sea domain, autoinhibition, activator, t-all, leukemia, oncogene, ank repeat, developmental protein, differentiation, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, nucleus, phosphoprotein, receptor, transcription, transcription regulation, transmembrane, signaling protein
• Biological source: Homo sapiens
• Cellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531
• Total number of polymer chains: 2
• Total formula weight: 54541.45

Authors

Gordon, W.R.,Blacklow, S.C. (deposition date: 2008-10-08, release date: 2008-12-23, Last modification date: 2023-09-06)

• Primary citation: Gordon, W.R.,Roy, M.,Vardar-Ulu, D.,Garfinkel, M.,Mansour, M.R.,Aster, J.C.,Blacklow, S.C.; Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.; Blood, 113:4381-4390, 2009; PubMed: 19075186; DOI: 10.1182/blood-2008-08-174748

Experimental method

X-RAY DIFFRACTION (2 Å)