3EM4
Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease
Summary for 3EM4
Entry DOI | 10.2210/pdb3em4/pdb |
Related | 3EM3 3EM6 |
Descriptor | Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | drug resistance, hypersusceptibility, protease inhibitor, hiv, atazanavir, aids, hydrolase, protease |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 4 |
Total formula weight | 45393.77 |
Authors | Prabu-Jeyabalan, M.,King, N.,Royer, C.,Schiffer, C. (deposition date: 2008-09-23, release date: 2009-09-01, Last modification date: 2024-03-13) |
Primary citation | Prabu-Jeyabalan, M.,King, N.,Bandaranayake, R.,Nalivaika, E.,Schiffer, C. Kinetic and Structural studies on atazanavir-specific I50L drug-resistant HIV-1 protease mutant To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report