3EGK

KNOBLE Inhibitor

Summary for 3EGK

Entry DOI	10.2210/pdb3egk/pdb
Related	1H8D 1K22 1YPG 2ZDA 2ZGX 2ZHQ
Descriptor	Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total)
Functional Keywords	blood clotting/hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, blood clotting-hydrolase inhibitor complex
Biological source	Homo sapiens (Human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P01050
Total number of polymer chains	3
Total formula weight	35754.08
Authors	Baum, B.,Heine, A.,Klebe, G.,Muenzel, M. (deposition date: 2008-09-10, release date: 2008-09-30, Last modification date: 2024-10-30)
Primary citation	Gerlach, C.,Munzel, M.,Baum, B.,Gerber, H.-D.,Craan, T.,Diederich, W.E.,Klebe, G. KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding Angew.Chem.Int.Ed.Engl., 46:9105-9109, 2007 Cited by PubMed: 17955562 DOI: 10.1002/anie.200703323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation