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3EGK

KNOBLE Inhibitor

Summary for 3EGK
Entry DOI10.2210/pdb3egk/pdb
Related1H8D 1K22 1YPG 2ZDA 2ZGX 2ZHQ
DescriptorThrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total)
Functional Keywordsblood clotting/hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, blood clotting-hydrolase inhibitor complex
Biological sourceHomo sapiens (Human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P01050
Total number of polymer chains3
Total formula weight35754.08
Authors
Baum, B.,Heine, A.,Klebe, G.,Muenzel, M. (deposition date: 2008-09-10, release date: 2008-09-30, Last modification date: 2023-11-15)
Primary citationGerlach, C.,Munzel, M.,Baum, B.,Gerber, H.-D.,Craan, T.,Diederich, W.E.,Klebe, G.
KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding
Angew.Chem.Int.Ed.Engl., 46:9105-9109, 2007
Cited by
PubMed: 17955562
DOI: 10.1002/anie.200703323
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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