3D9C

Crystal Structure PTP1B complex with aryl Seleninic acid

Summary for 3D9C

Entry DOI	10.2210/pdb3d9c/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid (3 entities in total)
Functional Keywords	inhibitor, covalent bond, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	37769.95
Authors	Abdo, M.,Liu, S.,Zhou, B.,Walls, C.D.,Knapp, S.,Zhang, Z.-Y. (deposition date: 2008-05-27, release date: 2008-09-23, Last modification date: 2024-02-21)
Primary citation	Abdo, M.,Liu, S.,Zhou, B.,Walls, C.D.,Wu, L.,Knapp, S.,Zhang, Z.Y. Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. J.Am.Chem.Soc., 130:13196-13197, 2008 Cited by PubMed: 18781746 DOI: 10.1021/ja804489m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation