3D7P
Crystal structure of human Transthyretin (TTR) at pH 4.0
Summary for 3D7P
Entry DOI | 10.2210/pdb3d7p/pdb |
Related | 1BMZ 3CBR |
Descriptor | Transthyretin (2 entities in total) |
Functional Keywords | wt-ttr, amyloid, transthyretin, acidic ph, native ttr, and crystal structure, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 27554.72 |
Authors | Palaninathan, S.K.,Mohamedmohaideen, N.N.,Snee, W.C.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2008-05-21, release date: 2008-08-12, Last modification date: 2023-08-30) |
Primary citation | Palaninathan, S.K.,Mohamedmohaideen, N.N.,Snee, W.C.,Kelly, J.W.,Sacchettini, J.C. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J.Mol.Biol., 382:1157-1167, 2008 Cited by PubMed: 18662699DOI: 10.1016/j.jmb.2008.07.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
Download full validation report