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3D48

Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

Summary for 3D48
Entry DOI10.2210/pdb3d48/pdb
Related1BP3 1F6F 1N9D 1RW5 2Q98
DescriptorProlactin, Prolactin receptor, CARBONATE ION, ... (4 entities in total)
Functional Keywordscytokine-cytokine receptor complex, four-helix bundle, glycoprotein, hormone, lactation, secreted, alternative splicing, membrane, receptor, transmembrane, hormone-hormone receptor complex, hormone/hormone receptor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: P01236
Membrane ; Single-pass type I membrane protein . Isoform 7: Secreted: P16471
Total number of polymer chains2
Total formula weight46717.89
Authors
Svensson, L.A.,Breinholt, J. (deposition date: 2008-05-14, release date: 2008-06-03, Last modification date: 2023-11-01)
Primary citationSvensson, L.A.,Bondensgaard, K.,Norskov-Lauritsen, L.,Christensen, L.,Becker, P.,Andersen, M.D.,Maltesen, M.J.,Rand, K.D.,Breinholt, J.
Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
J.Biol.Chem., 283:19085-19094, 2008
Cited by
PubMed: 18467331
DOI: 10.1074/jbc.M801202200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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