3D0B
Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90
Summary for 3D0B
| Entry DOI | 10.2210/pdb3d0b/pdb |
| Descriptor | Heat shock protein HSP 90-alpha, 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide (3 entities in total) |
| Functional Keywords | hsp90, heat shock protein 90, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P07900 |
| Total number of polymer chains | 1 |
| Total formula weight | 26534.82 |
| Authors | Barta, T.E.,Veal, J.M.,Huang, K.H.,Hall, S.H. (deposition date: 2008-05-01, release date: 2008-06-17, Last modification date: 2024-04-10) |
| Primary citation | Barta, T.E.,Veal, J.M.,Rice, J.W.,Partridge, J.M.,Fadden, R.P.,Ma, W.,Jenks, M.,Geng, L.,Hanson, G.J.,Huang, K.H.,Barabasz, A.F.,Foley, B.E.,Otto, J.,Hall, S.E. Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 BIOORG.MED.CHEM.LETT., 18:3517-3521, 2008 Cited by PubMed: 18511277DOI: 10.1016/j.bmcl.2008.05.023 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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