3CZN

Golgi alpha-mannosidase II (D204A nucleophile mutant) in complex with GnMan5Gn

Summary for 3CZN

• Entry DOI: 10.2210/pdb3czn/pdb
• Related: 1HTY 1HWW 1HXK 1PS2 1QWN 1QWU 1QX1 1R33 1R34 2ALW 2F7O 2F7P 2F7Q 2F7R 3BUB 3BUD 3BUI 3BUP 3BUQ 3BVT 3BVU 3BVV 3BVW 3BVX 3CV5 3CZS 3D4Y 3D4Z 3D50 3D51 3D52
• Descriptor: Alpha-mannosidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hydrolase, glycosyl hydrolase, mannosidase, n-terminal alpha-beta domain, three helix bundle, 2 c-terminal beta barrels, glycosidase, golgi apparatus, membrane, metal-binding, signal-anchor, transmembrane
• Biological source: Drosophila melanogaster (Fruit fly)
• Total number of polymer chains: 1
• Total formula weight: 121179.32

Authors

Shah, N.,Rose, D.R. (deposition date: 2008-04-29, release date: 2008-06-24, Last modification date: 2021-10-20)

• Primary citation: Shah, N.,Kuntz, D.A.,Rose, D.R.; Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site.; Proc.Natl.Acad.Sci.Usa, 105:9570-9575, 2008; PubMed: 18599462; DOI: 10.1073/pnas.0802206105

Experimental method

X-RAY DIFFRACTION (1.4 Å)