3CSE

Candida glabrata Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Summary for 3CSE

Entry DOI	10.2210/pdb3cse/pdb
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	protein-ligand complex, reductase, oxidoreductase
Biological source	Candida glabrata (yeast)
Total number of polymer chains	2
Total formula weight	54970.24
Authors	Liu, J.,Anderson, A.C. (deposition date: 2008-04-09, release date: 2008-11-25, Last modification date: 2024-02-21)
Primary citation	Liu, J.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase. Chem.Biol., 15:990-996, 2008 Cited by PubMed: 18804036 DOI: 10.1016/j.chembiol.2008.07.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation