Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005575 | cellular_component | cellular_component |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005575 | cellular_component | cellular_component |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NDP A 301 |
Chain | Residue |
A | VAL10 |
A | LYS57 |
A | THR58 |
A | VAL77 |
A | SER78 |
A | ARG79 |
A | ASN96 |
A | SER97 |
A | LEU98 |
A | ILE121 |
A | GLY123 |
A | ALA11 |
A | GLY124 |
A | GLU125 |
A | ILE126 |
A | TYR127 |
A | GLN129 |
A | N22302 |
A | HOH419 |
A | HOH433 |
A | HOH444 |
A | HOH447 |
A | ILE19 |
A | HOH511 |
A | HOH519 |
A | HOH556 |
A | GLY20 |
A | GLY23 |
A | ASN24 |
A | LEU25 |
A | GLY55 |
A | ARG56 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE N22 A 302 |
Chain | Residue |
A | ILE9 |
A | VAL10 |
A | ALA11 |
A | LEU25 |
A | GLU32 |
A | MET33 |
A | PHE36 |
A | SER61 |
A | ILE62 |
A | ILE121 |
A | TYR127 |
A | THR140 |
A | NDP301 |
A | HOH433 |
A | HOH545 |
site_id | AC3 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NDP B 301 |
Chain | Residue |
B | VAL10 |
B | ALA11 |
B | ILE19 |
B | GLY20 |
B | GLY23 |
B | ASN24 |
B | LEU25 |
B | GLY55 |
B | ARG56 |
B | LYS57 |
B | THR58 |
B | VAL77 |
B | SER78 |
B | ARG79 |
B | ASN96 |
B | SER97 |
B | LEU98 |
B | ILE121 |
B | GLY123 |
B | GLY124 |
B | GLU125 |
B | ILE126 |
B | TYR127 |
B | GLN129 |
B | N22302 |
B | HOH426 |
B | HOH460 |
B | HOH463 |
B | HOH490 |
B | HOH494 |
B | HOH507 |
B | HOH583 |
B | HOH589 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE N22 B 302 |
Chain | Residue |
B | ILE9 |
B | VAL10 |
B | ALA11 |
B | LEU25 |
B | GLU32 |
B | MET33 |
B | PHE36 |
B | SER61 |
B | LEU69 |
B | ILE121 |
B | TYR127 |
B | THR140 |
B | NDP301 |
B | HOH463 |
B | HOH543 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGfqgnLPWrlak.EmkyFrevT |
Chain | Residue | Details |
A | GLY18-THR40 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | LEU25 | |
A | GLU32 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
B | LEU25 | |
B | GLU32 | |