3CFQ

Crystal structure of human wild-type transthyretin in complex with diclofenac

Summary for 3CFQ

Entry DOI	10.2210/pdb3cfq/pdb
Related	1dvx 3CFM 3CFN 3CFT
Descriptor	Transthyretin, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID (3 entities in total)
Functional Keywords	transthyretin, thyroxin, familial amyloid polyneurophaty, disease mutation, glycoprotein, hormone, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	26515.32
Authors	Lima, L.-M.T.R.,Foguel, D.,Polikarpov, I. (deposition date: 2008-03-04, release date: 2009-03-03, Last modification date: 2023-08-30)
Primary citation	Lima, L.M.,Silva, V.D.,Palmieri, L.D.,Oliveira, M.C.,Foguel, D.,Polikarpov, I. Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18:100-110, 2010 Cited by PubMed: 19954984 DOI: 10.1016/j.bmc.2009.11.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation