3C6T
Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14
Summary for 3C6T
Entry DOI | 10.2210/pdb3c6t/pdb |
Related | 3C6U |
Descriptor | Reverse transcriptase, 2-[3-chloro-5-(3-chloro-5-cyanophenoxy)phenoxy]-N-(2-chloro-4-sulfamoylphenyl)acetamide, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, aids, aspartyl protease, capsid maturation, capsid protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger |
Biological source | HIV-1 M:B_HXB2R More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 117153.51 |
Authors | Yan, Y.,Prasad, S. (deposition date: 2008-02-05, release date: 2008-04-22, Last modification date: 2023-08-30) |
Primary citation | Tucker, T.J.,Saggar, S.,Sisko, J.T.,Tynebor, R.M.,Williams, T.M.,Felock, P.J.,Flynn, J.A.,Lai, M.T.,Liang, Y.,McGaughey, G.,Liu, M.,Miller, M.,Moyer, G.,Munshi, V.,Perlow-Poehnelt, R.,Prasad, S.,Sanchez, R.,Torrent, M.,Vacca, J.P.,Wan, B.L.,Yan, Y. The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. Bioorg.Med.Chem.Lett., 18:2959-2966, 2008 Cited by PubMed: 18396399DOI: 10.1016/j.bmcl.2008.03.064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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