3C49

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor KU0058948

Summary for 3C49

• Entry DOI: 10.2210/pdb3c49/pdb
• Related: 2PA9 3C49
• Descriptor: Poly(ADP-ribose) polymerase 3, 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one (3 entities in total)
• Functional Keywords: enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, alternative splicing, glycosyltransferase, nad, nucleus, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9Y6F1
• Total number of polymer chains: 1
• Total formula weight: 40132.49

Authors

Lehtio, L.,Karlberg, T.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Busam, R.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Helleday, T.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van den Berg, S.,Welin, M.,Weigelt, J.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-29, release date: 2008-02-12, Last modification date: 2023-08-30)

• Primary citation: Lehtio, L.,Jemth, A.S.,Collins, R.,Loseva, O.,Johansson, A.,Markova, N.,Hammarstrom, M.,Flores, A.,Holmberg-Schiavone, L.,Weigelt, J.,Helleday, T.,Schuler, H.,Karlberg, T.; Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.; J.Med.Chem., 52:3108-3111, 2009; PubMed: 19354255; DOI: 10.1021/jm900052j

Experimental method

X-RAY DIFFRACTION (2.8 Å)