3C1K
Crystal structure of thrombin in complex with inhibitor 15
Summary for 3C1K
Entry DOI | 10.2210/pdb3c1k/pdb |
Descriptor | Prothrombin, Hirugen, 2-{3-[(benzylsulfonyl)amino]-6-methyl-2-oxopyridin-1(2H)-yl}-N-({1-[2-(tert-butylamino)-2-oxoethyl]-4-methyl-1H-imidazol-5-yl}methyl)acetamide, ... (4 entities in total) |
Functional Keywords | thrombin, thrombin inhibitor complex, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28511 |
Total number of polymer chains | 2 |
Total formula weight | 35114.14 |
Authors | |
Primary citation | Isaacs, R.C.,Solinsky, M.G.,Cutrona, K.J.,Newton, C.L.,Naylor-Olsen, A.M.,McMasters, D.R.,Krueger, J.A.,Lewis, S.D.,Lucas, B.J.,Kuo, L.C.,Yan, Y.,Lynch, J.J.,Lyle, E.A. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles. Bioorg.Med.Chem.Lett., 18:2062-2066, 2008 Cited by PubMed: 18291642DOI: 10.1016/j.bmcl.2008.01.098 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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