3BZF

The human non-classical major histocompatibility complex molecule HLA-E

Summary for 3BZF

• Entry DOI: 10.2210/pdb3bzf/pdb
• Related: 3BZE
• Descriptor: HLA class I histocompatibility antigen, alpha chain E, Beta-2-microglobulin, leader peptide of HLA class I histocompatibility antigen, Cw-7 alpha chain, ... (4 entities in total)
• Functional Keywords: mhc fold, glycoprotein, immune response, membrane, mhc i, polymorphism, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, host-virus interaction, ubl conjugation, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P13747 P10321; Secreted: P61769
• Total number of polymer chains: 6
• Total formula weight: 88830.60

Authors

Hoare, H.L.,Sullivan, L.C.,Ely, L.K.,Beddoe, T.,Henderson, K.N.,Lin, J.,Clements, C.S.,Reid, H.H.,Brooks, A.G.,Rossjohn, J. (deposition date: 2008-01-17, release date: 2008-04-29, Last modification date: 2023-11-01)

• Primary citation: Hoare, H.L.,Sullivan, L.C.,Clements, C.S.,Ely, L.K.,Beddoe, T.,Henderson, K.N.,Lin, J.,Reid, H.H.,Brooks, A.G.,Rossjohn, J.; Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors; J.Mol.Biol., 377:1297-1303, 2008; PubMed: 18339401; DOI: 10.1016/j.jmb.2008.01.098

Experimental method

X-RAY DIFFRACTION (2.5 Å)