3BX7

Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4

Summary for 3BX7

• Entry DOI: 10.2210/pdb3bx7/pdb
• Related: 3BX8
• Descriptor: CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2 (3 entities in total)
• Functional Keywords: protein design, protein-protein complex, glycoprotein, immunoglobulin domain, polymorphism, transmembrane protein, de novo protein, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P16410
• Total number of polymer chains: 2
• Total formula weight: 33502.81

Authors

Schonfeld, D.L.,Chatwell, L.,Skerra, A. (deposition date: 2008-01-11, release date: 2009-01-20, Last modification date: 2023-08-30)

• Primary citation: Schonfeld, D.L.,Matschiner, G.,Chatwell, L.,Trentmann, S.,Schlehuber, S.,Hohlbaum, A.,Skerra, A.; High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)