3BX7

Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4

Summary for 3BX7
Related3BX8
DescriptorCYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2 (3 entities in total)
Functional Keywordsprotein design, protein-protein complex, glycoprotein, immunoglobulin domain, polymorphism, transmembrane protein, de novo protein, protein binding
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Single-pass type I membrane protein: P16410
Total number of polymer chains2
Total formula weight33502.81
Authors
Schonfeld, D.L.,Chatwell, L.,Skerra, A. (deposition date: 2008-01-11, release date: 2009-01-20, Last modification date: 2011-07-13)
Primary citationChatwell, L.,Hohlbaum, A.,Matschiner, G.,Schlehuber, S.,Schonfeld, D.L.,Skerra, A.,Trentmann, S.
High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation
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178747

PDB entries from 2021-06-09