3BX7
Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
Summary for 3BX7
Entry DOI | 10.2210/pdb3bx7/pdb |
Related | 3BX8 |
Descriptor | CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2 (3 entities in total) |
Functional Keywords | protein design, protein-protein complex, glycoprotein, immunoglobulin domain, polymorphism, transmembrane protein, de novo protein, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P16410 |
Total number of polymer chains | 2 |
Total formula weight | 33502.81 |
Authors | Schonfeld, D.L.,Chatwell, L.,Skerra, A. (deposition date: 2008-01-11, release date: 2009-01-20, Last modification date: 2023-08-30) |
Primary citation | Schonfeld, D.L.,Matschiner, G.,Chatwell, L.,Trentmann, S.,Schlehuber, S.,Hohlbaum, A.,Skerra, A. High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report