3BQR

Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with an imidazo-pyridazine ligand

Summary for 3BQR

• Entry DOI: 10.2210/pdb3bqr/pdb
• Descriptor: Death-associated protein kinase 3, 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid, S-1,2-PROPANEDIOL, ... (5 entities in total)
• Functional Keywords: death associated kinase, dapk3, zip kinase, zipk, dap kinase 3, dap like kinase, dlk, structural genomics consortium, sgc, apoptosis, atp-binding, chromatin regulator, nucleotide-binding, nucleus, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus : O43293
• Total number of polymer chains: 1
• Total formula weight: 33115.75

Authors

Filippakopoulos, P.,Rellos, P.,Fedorov, O.,Niesen, F.,Pike, A.C.W.,Pilka, E.S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-12-20, release date: 2008-02-26, Last modification date: 2023-08-30)

• Primary citation: Filippakopoulos, P.,Rellos, P.,Fedorov, O.,Niesen, F.,Pike, A.C.W.,Pilka, E.S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Knapp, S.; Crystal Structure of Human Death Associated Protein Kinase 3 (DAPK3) in Complex with an Imidazo-Pyridazine Ligand.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)