3BN9

Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2

Summary for 3BN9

• Entry DOI: 10.2210/pdb3bn9/pdb
• Related: 3BN5
• Descriptor: Membrane-type serine protease 1, E2 Fab Light Chain, E2 Fab Heavy Chain, ... (6 entities in total)
• Functional Keywords: antibody-protease complex, protein-protein complex, enzyme-inhibitor complex, disease mutation, glycoprotein, hydrolase, membrane, polymorphism, serine protease, signal-anchor, transmembrane
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane ; Single-pass type II membrane protein : Q9Y5Y6
• Total number of polymer chains: 6
• Total formula weight: 154648.53

Authors

Farady, C.J.,Schneider, E.L.,Egea, P.F.,Goetz, D.H.,Craik, C.S. (deposition date: 2007-12-13, release date: 2008-09-09, Last modification date: 2023-08-30)

• Primary citation: Farady, C.J.,Egea, P.F.,Schneider, E.L.,Darragh, M.R.,Craik, C.S.; Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition; J.Mol.Biol., 380:351-360, 2008; PubMed: 18514224; DOI: 10.1016/j.jmb.2008.05.009

Experimental method

X-RAY DIFFRACTION (2.173 Å)