3BN9
Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, A) | Membrane-type serine protease 1 | polymer | 241 | 26447.7 | 2 | UniProt (Q9Y5Y6) Pfam (PF00089) | Homo sapiens (human) | Serine protease 14, Matriptase, Suppressor of tumorigenicity protein 14, MT-SP1, Prostamin, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein |
| 2 | B, E (C, E) | E2 Fab Light Chain | polymer | 214 | 23245.8 | 2 | Homo sapiens (human) | ||
| 3 | C, F (D, F) | E2 Fab Heavy Chain | polymer | 257 | 27131.3 | 2 | Pfam (PF07686) UniProt (by SIFTS) (P01764) | Homo sapiens (human) | |
| 4 | G, H, I, J, K... (B, C, D, A, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 5 | M, T (C, E) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | AA, V, W, X, Y... (F, B, C, D, A...) | water | water | 18.0 | 824 | Chemie (HOH) |
Sequence modifications
B, A: 16 - 244 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 731 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 153649.5 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 999.0 | |
| All* | Total formula weight | 154648.5 |
