3BKK
Tesis ACE co-crystal structure with ketone ACE inhibitor kAF
Summary for 3BKK
Entry DOI | 10.2210/pdb3bkk/pdb |
Related | 1O86 1O8A 1UZE 1UZF 2IUL 2IUX 3BKL |
Descriptor | Angiotensin-converting enzyme, somatic isoform, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | enzyme-inhibitor complex, gem-diol, domain-selective, carboxypeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, phosphoprotein, protease, secreted, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 69921.05 |
Authors | Watermeyer, J.M.,Kroger, W.L.,O'Neill, H.G.,Sewell, B.T.,Sturrock, E.D. (deposition date: 2007-12-07, release date: 2008-06-10, Last modification date: 2023-08-30) |
Primary citation | Watermeyer, J.M.,Kroger, W.L.,O'Neill, H.G.,Sewell, B.T.,Sturrock, E.D. Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme Biochemistry, 47:5942-5950, 2008 Cited by PubMed: 18457420DOI: 10.1021/bi8002605 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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