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3BC5

X-ray crystal structure of human ppar gamma with 2-(5-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2h-1,2,3-triazol-4-yl)acetic acid

Summary for 3BC5
Entry DOI10.2210/pdb3bc5/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, (5-{3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}-2-phenyl-2H-1,2,3-triazol-4-yl)acetic acid (3 entities in total)
Functional Keywordsligand-binding domain, nuclear hormone receptor, transcription factor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphorylation, polymorphism, transcription regulation, zinc, zinc-finger, transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: P37231
Total number of polymer chains1
Total formula weight34246.61
Authors
Muckelbauer, J.K. (deposition date: 2007-11-12, release date: 2008-11-18, Last modification date: 2024-02-21)
Primary citationZhang, H.,Ryono, D.E.,Devasthale, P.,Wang, W.,O'Malley, K.,Farrelly, D.,Gu, L.,Harrity, T.,Cap, M.,Chu, C.,Locke, K.,Zhang, L.,Lippy, J.,Kunselman, L.,Morgan, N.,Flynn, N.,Moore, L.,Hosagrahara, V.,Zhang, L.,Kadiyala, P.,Xu, C.,Doweyko, A.M.,Bell, A.,Chang, C.,Muckelbauer, J.,Zahler, R.,Hariharan, N.,Cheng, P.T.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg.Med.Chem.Lett., 19:1451-1456, 2009
Cited by
PubMed: 19201606
DOI: 10.1016/j.bmcl.2009.01.030
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.27 Å)
Structure validation

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