3B7J

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone

Summary for 3B7J

• Entry DOI: 10.2210/pdb3b7j/pdb
• Related: 2GLL 2GLM 2GLP 2GLV
• Descriptor: (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... (5 entities in total)
• Functional Keywords: fabz complex, juglone, cytoplasm, lipid a biosynthesis, lipid synthesis, lyase
• Biological source: Helicobacter pylori (Campylobacter pylori)
• Cellular location: Cytoplasm (By similarity): Q5G940
• Total number of polymer chains: 6
• Total formula weight: 110638.80

Authors

Zhang, L.,Kong, Y.H.,Wu, D.,Shen, X.,Jiang, H.L. (deposition date: 2007-10-31, release date: 2008-09-02, Last modification date: 2023-11-01)

Primary citation

Kong, Y.H.,Zhang, L.,Yang, Z.Y.,Han, C.,Hu, L.H.,Jiang, H.L.,Shen, X.
Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization
ACTA PHARMACOL.SIN., 29:870-876, 2008

PubMed Abstract: To investigate the inhibition features of the natural product juglone (5- hydroxy-1,4-naphthoquinone) against the three key enzymes from Helicobacter pylori (cystathionine gamma-synthase [HpCGS], malonyl-CoA:acyl carrier protein transacylase [HpFabD], and beta-hydroxyacyl-ACP dehydratase [HpFabZ]).

PubMed: 18565285
DOI: 10.1111/j.1745-7254.2008.00808.x

Experimental method

X-RAY DIFFRACTION (2.4 Å)