3B6A

Crystal structure of the Streptomyces coelicolor TetR family protein ActR in complex with actinorhodin

Summary for 3B6A

• Entry DOI: 10.2210/pdb3b6a/pdb
• Related: 2OPT 3B6C
• Descriptor: ActR protein, 2,2'-[(1R,1'R,3S,3'S)-6,6',9,9'-tetrahydroxy-1,1'-dimethyl-5,5',10,10'-tetraoxo-3,3',4,4',5,5',10,10'-octahydro-1H,1'H-8,8'-bibenzo[g]isochromene-3,3'-diyl]diacetic acid (2 entities in total)
• Functional Keywords: transcriptional repressor, dna-binding protein, tetr family, actinorhodin, ligand, transcription regulation, transcription
• Biological source: Streptomyces coelicolor
• Total number of polymer chains: 8
• Total formula weight: 206680.76

Authors

Willems, A.R.,Junop, M.S. (deposition date: 2007-10-28, release date: 2008-02-05, Last modification date: 2023-08-30)

• Primary citation: Willems, A.R.,Tahlan, K.,Taguchi, T.,Zhang, K.,Lee, Z.Z.,Ichinose, K.,Junop, M.S.,Nodwell, J.R.; Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA.; J.Mol.Biol., 376:1377-1387, 2008; PubMed: 18207163; DOI: 10.1016/j.jmb.2007.12.061

Experimental method

X-RAY DIFFRACTION (3.05 Å)