3B4F
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Summary for 3B4F
Entry DOI | 10.2210/pdb3b4f/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitors, sulfonamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc, lyase(oxo-acid) |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29885.42 |
Authors | Guzel, o.,Temperini, c.,Innocenti, a.,Scozzafava, A.,Salman, a.,Supuran, c.t. (deposition date: 2007-10-24, release date: 2008-01-22, Last modification date: 2023-08-30) |
Primary citation | Guzel, O.,Temperini, C.,Innocenti, A.,Scozzafava, A.,Salman, A.,Supuran, C.T. Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 18:152-158, 2008 Cited by PubMed: 18024029DOI: 10.1016/j.bmcl.2007.10.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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