3B3O

Structure of neuronal nos heme domain in complex with a inhibitor (+-)-n1-{cis-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-n2-(4'-chlorobenzyl)ethane-1,2-diamine

Summary for 3B3O

Entry DOI	10.2210/pdb3b3o/pdb
Related	3B3M 3B3N 3B3P
Descriptor	Nitric oxide synthase, brain, ACETATE ION, ZINC ION, ... (7 entities in total)
Functional Keywords	nitric oxide synthase, heme enzyme, inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, iron, membrane, metal-binding, nadp, oxidoreductase
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	2
Total formula weight	100271.87
Authors	Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2007-10-22, release date: 2008-11-04, Last modification date: 2024-02-21)
Primary citation	Igarashi, J.,Li, H.,Jamal, J.,Ji, H.,Fang, J.,Lawton, G.R.,Silverman, R.B.,Poulos, T.L. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. J.Med.Chem., 52:2060-2066, 2009 Cited by PubMed: 19296678 DOI: 10.1021/jm900007a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation