3B3N

Structure of neuronal NOS heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine

Summary for 3B3N

Entry DOI	10.2210/pdb3b3n/pdb
Related	3B3M 3B3O 3B3P
Descriptor	Nitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total)
Functional Keywords	nitric oxide synthase, heme enzyme, inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, iron, membrane, metal-binding, nadp, oxidoreductase
Biological source	Rattus norvegicus (Rat)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains	2
Total formula weight	99994.68
Authors	Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2007-10-22, release date: 2008-07-15, Last modification date: 2024-02-21)
Primary citation	Ji, H.,Stanton, B.Z.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J.Am.Chem.Soc., 130:3900-3914, 2008 Cited by PubMed: 18321097 DOI: 10.1021/ja0772041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation