3AUN

Crystal structure of the rat vitamin D receptor ligand binding domain complexed with YR335 and a synthetic peptide containing the NR2 box of DRIP 205

Summary for 3AUN

• Entry DOI: 10.2210/pdb3aun/pdb
• Related: 2ZFX
• Descriptor: Vitamin D3 receptor, DRIP 205 NR2 box peptide, (2R)-2-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}butane-1,4-diol, ... (4 entities in total)
• Functional Keywords: binding sites, biphenyl compounds, protein binding, tertiary, rats, receptors, calcitriol, vitamin d, transcription
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Nucleus: P13053 Q15648
• Total number of polymer chains: 2
• Total formula weight: 32099.05

Authors

Kakuda, S.,Takimoto-Kamimura, M. (deposition date: 2011-02-10, release date: 2012-02-15, Last modification date: 2023-11-01)

• Primary citation: Demizu, Y.,Takahashi, T.,Kaneko, F.,Sato, Y.,Okuda, H.,Ochiai, E.,Horie, K.,Takagi, K.,Kakuda, S.,Takimoto-Kamimura, M.,Kurihara, M.; Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands; Bioorg.Med.Chem.Lett., 21:6104-6107, 2011; PubMed: 21889334; DOI: 10.1016/j.bmcl.2011.08.047

Experimental method

X-RAY DIFFRACTION (1.81 Å)