3AQA
Crystal structure of the human BRD2 BD1 bromodomain in complex with a BRD2-interactive compound, BIC1
Summary for 3AQA
Entry DOI | 10.2210/pdb3aqa/pdb |
Descriptor | Bromodomain-containing protein 2, 1-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | structural genomics, riken structural genomics/proteomics initiative, rsgi, helical bundle, acetyl-lysine recognition, acetylated histone h4, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P25440 |
Total number of polymer chains | 3 |
Total formula weight | 46323.36 |
Authors | Umehara, T.,Nakamura, Y.,Terada, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2010-10-27, release date: 2011-05-18, Last modification date: 2023-11-15) |
Primary citation | Ito, T.,Umehara, T.,Sasaki, K.,Nakamura, Y.,Nishino, N.,Terada, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,Ito, A.,Yoshida, M. Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors Chem.Biol., 18:495-507, 2011 Cited by PubMed: 21513886DOI: 10.1016/j.chembiol.2011.02.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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