3ABU
Crystal Structure of LSD1 in complex with a 2-PCPA derivative, S1201
Summary for 3ABU
Entry DOI | 10.2210/pdb3abu/pdb |
Related | 2dw4 2uxx 2z5u 3abt |
Descriptor | Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3R,3aS)-3-[2-(benzyloxy)-3-fluorophenyl]-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (2 entities in total) |
Functional Keywords | amine oxidase, histone demethylase, tower domain, h3k4, structural genomics, riken structural genomics/proteomics initiative, rsgi, chromatin regulator, developmental protein, fad, nucleus, oxidoreductase, phosphoprotein, repressor, transcription, transcription regulation, nppsfa, national project on protein structural and functional analyses |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : O60341 |
Total number of polymer chains | 1 |
Total formula weight | 74696.08 |
Authors | Mimasu, S.,Umezawa, N.,Sato, S.,Higuchi, T.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2009-12-21, release date: 2010-07-07, Last modification date: 2023-11-01) |
Primary citation | Mimasu, S.,Umezawa, N.,Sato, S.,Higuchi, T.,Umehara, T.,Yokoyama, S. Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1 Biochemistry, 49:6494-6503, 2010 Cited by PubMed: 20568732DOI: 10.1021/bi100299r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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