39PL

SARS-CoV-2 Main Protease with Secutrelvir

This is a non-PDB format compatible entry.

Summary for 39PL

• Entry DOI: 10.2210/pdb39pl/pdb
• Related: 39KL
• Descriptor: 3C-like proteinase nsp5, 1-(2-azanylideneethyl)-6-[6,6-bis(fluoranyl)-2-azaspiro[3.3]heptan-2-yl]-5-(3-chloranyl-4-fluoranyl-phenyl)-3-(5-chloranylpyridin-3-yl)pyrimidine-2,4-dione, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: sars-cov-2, main protease, secutrelvir, covalent inhibitor, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 34283.81

Authors

Al-Homoudi, A.I.,Brunzelle, J.S.,Kovari, L.C. (deposition date: 2026-10-21, release date: 2026-11-04)

• Primary citation: Al-Homoudi, A.I.,Brunzelle, J.S.,Kovari, L.C.; Molecular Determinants of Differential Resistance Across Approved and Next-Generation SARS-CoV-2 Main Protease Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.59 Å)