39GO

Crystal structure of a bacterial DOT1L methyl-transferase in complex with S-adenosyl homocysteine

Replaces:  9NE1

Summary for 39GO

• Entry DOI: 10.2210/pdb39go/pdb
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• Functional Keywords: methyl-transferase, product complex, bacteria, transferase
• Biological source: Legionella pneumophila
• Total number of polymer chains: 1
• Total formula weight: 26168.15

Authors

Mondino, S.,Dalla Rizza, J.,Larrieux, N.,Buschiazzo, A. (deposition date: 2026-10-07, release date: 2026-11-04)

• Primary citation: Nicchi, S.,Mondino, S.,Rusniok, C.,Mahtal, N.,Raynal, B.,ElJ, R.,Quentin, G.G.,Dalla Rizza, J.,Larrieux, N.,Martyn, J.E.,Schoeler, H.,Schmutz, S.,Matondo, M.,Buschiazzo, A.,Buchrieser, C.,Rolando, M.; The bacterial effector LpDot1 methylates SFPQ to hijack paraspeckle dynamics and alternative splicing immune responses; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)