38HJ

Crystal structure of the transpeptidase domain of a Y422F mutant of PBP2 from Neisseria gonorrhoeae strain H041 acylated by cefoperazone

This is a non-PDB format compatible entry.

Summary for 38HJ

• Entry DOI: 10.2210/pdb38hj/pdb
• Descriptor: Probable peptidoglycan D,D-transpeptidase PenA, (2R)-2-[(1R)-1-{[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (3 entities in total)
• Functional Keywords: neisseria gonorrhoeae penicillin-binding protein site-directed mutant cefoperazone, ligase
• Biological source: Neisseria gonorrhoeae
• Total number of polymer chains: 1
• Total formula weight: 35879.05

Authors

Bala, S.,Stratton, C.M.,Davies, C. (deposition date: 2026-08-27, release date: 2026-09-16)

• Primary citation: Stratton, C.M.,Bala, S.,Bivins, M.M.,Nicholas, R.A.,Davies, C.; Energetic coupling of an active site residue in penicillin-binding protein 2 from Neisseria gonorrhoeae with a resistance-associated conformational switch in the beta3-beta4 loop; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)