38FW

CYP3A4 bound to ketoconazole

Summary for 38FW

• Entry DOI: 10.2210/pdb38fw/pdb
• EMDB information: 78782
• Descriptor: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE, ... (4 entities in total)
• Functional Keywords: inhibited complex, cytochrome p450, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 172311.48

Authors

Orta, A.K.,Fraser, J.S. (deposition date: 2026-08-24, release date: 2026-09-30)

• Primary citation: Orta, A.K.,Fraser, J.S.; Structural analysis of CYP3A4 inhibition by Cryo-EM; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.74 Å)