37LV

NPC1 expressed from Sf9 and purified at pH 5.5

Summary for 37LV

• Entry DOI: 10.2210/pdb37lv/pdb
• Related: 37LU
• EMDB information: 78289 78290
• Descriptor: NPC intracellular cholesterol transporter 1, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: transporter, viral entry, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 147732.40

Authors

Wu, X.,Yan, N. (deposition date: 2026-07-25, release date: 2026-09-30)

• Primary citation: Wu, X.,Dehghani-Ghahnaviyeh, S.,Rasouli, A.,Malona, J.A.,Antalek, M.,Jones, L.H.,Fan, X.,Peng, A.,Tajkhorshid, E.,Qian, H.,Yan, N.; Conformation switch of NPC1 epitomizes a lumen-to-membrane alternating access for nonpolar substrates; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)