37HF

PCSK9 bound to small molecule inhibitor AZD-0780

This is a non-PDB format compatible entry.

Summary for 37HF

• Entry DOI: 10.2210/pdb37hf/pdb
• Descriptor: Propeptide of Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: pcsk9, azd0780, c-terminal domain, ldl receptor regulation, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 144622.73

Authors

Abramyan, T.,Janczyk, P.L.,Papoian, G.A. (deposition date: 2026-07-21, release date: 2026-08-12)

• Primary citation: Petrosyan, G.,Altunyan, V.,Ghukasyan, T.,Abramyan, T.M.,Arakelov, G.,Davtyan, A.,Aghajanyan, T.,Nakipov, I.,Navasardyan, G.,Fahradyan, A.,Tunanyan, H.,Simonyan, A.,Janczyk, P.L.,De Silva, D.,Saribekyan, H.,Tsidilkovski, L.,Arakelov, V.,Ginoyan, N.,Mnatsakanyan, H.,Ratnikov, M.,Smbatyan, K.,Papoyan, A.,Papoian, G.A.; Overcoming the accuracy-generalization tradeoff in docking and scoring for prospective virtual screening; Biorxiv, 2026; DOI: 10.64898/2026.08.03.742480

Experimental method

X-RAY DIFFRACTION (2.072 Å)