36XI

Cryo-EM structure of SLC6A19-ACE2 complex with Compound 20

This is a non-PDB format compatible entry.

Summary for 36XI

• Entry DOI: 10.2210/pdb36xi/pdb
• EMDB information: 77945
• Descriptor: Sodium-dependent neutral amino acid transporter B(0)AT1, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: membrane protein complex, neutral amino acid transport, sodium-dependent, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 316239.35

Authors

Wasilko, D.J.,Wu, H. (deposition date: 2026-07-05, release date: 2026-11-11)

• Primary citation: Wang, T.,Dowling, M.S.,Zhou, D.,Wasilko, D.J.,Tu, M.,Feliers, D.,Bernardo, B.,Tillotson, J.,Ma, W.,Brown, J.,Johnson, Z.,Lees, J.A.,Fensome, A.,Shavnya, A.,Clemens, J.,Coffey, S.,Blakemore, C.A.,Avery, M.,Tuttle, J.B.,Hudson, P.,Korczynska, M.,Murray, J.,Williams, J.,Xiao, J.,Dutra, J.,Hernandez, D.,Hesp, K.D.,Mascitti, V.,Jagarlapudi, S.,Keenan, R.,Ward, J.,Barnes, R.,Jordan, E.,Ochocki, N.,Callahan, D.,Steen, K.,Kalgutkar, A.S.,Fonseca, K.R.,Sharma, R.,Ferguson, N.,King-Ahmad, A.,Bessire, A.J.,Moody, A.,Maurer, T.S.,Stock, I.A.,Sommese, R.,Phillips, T.,Loria, P.M.,Wu, H.,Hepworth, D.,Sammons, M.F.,Zhang, L.,Zhang, Y.; Structure-Guided Discovery of Orally Bioavailable Allosteric SLC6A19 Inhibitors that Promote Urinary Amino Acid Excretion In Vivo; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c02154

Experimental method

ELECTRON MICROSCOPY (2.75 Å)