36XC

NNVL bound to inhibitor compound 112 (YT-IV-239B)

This is a non-PDB format compatible entry.

Summary for 36XC

• Entry DOI: 10.2210/pdb36xc/pdb
• Related: 36WT
• EMDB information: 77930 77939
• Descriptor: Ubiquitin-like domain-containing protein,Nuclear valosin-containing protein-like, Ply-histidine substrate mimic, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: ribosome assembly aaa+ protein, translocase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 480431.75

Authors

Erzberger, J.P.,Cruz, V.E. (deposition date: 2026-07-05, release date: 2026-11-11)

• Primary citation: Tao, Y.,Guo, H.H.,Cruz, V.E.,Reddy, D.,Leach, A.,Williams, N.S.,Aurora, A.B.,Khivansara, V.,Han, Y.,Erzberger, J.P.,Nijhawan, D.,De Brabander, J.K.; Discovery and Optimization of Anticancer Dibenzothiazepinones That Target the Ribosome Biogenesis Factor NVL; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c02184

Experimental method

ELECTRON MICROSCOPY (2.59 Å)