36UP

S. aureus DNA Gyrase in complex with OSUAB-0284 and DNA

This is a non-PDB format compatible entry.

Summary for 36UP

• Entry DOI: 10.2210/pdb36up/pdb
• EMDB information: 77872
• Descriptor: DNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), DNA Gyrase subunit B, DNA Gyrase subunit A, 6-[({(2r,5S)-2-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-1,3-dioxan-5-yl}amino)methyl]-2H-pyrazino[2,3-b][1,4]oxazin-3(4H)-one, ... (4 entities in total)
• Functional Keywords: topoisomerase, nbti, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Staphylococcus aureus subsp. aureus N315; More
• Total number of polymer chains: 4
• Total formula weight: 169200.35

Authors

Wheat, C.T.,Bell, C.E. (deposition date: 2026-07-01, release date: 2026-10-07)

• Primary citation: Mann, C.A.,West, J.C.,Cassel, S.R.,Wheat, C.T.,Landgraf, A.D.,Tomkovicz, J.V.,Zhao, X.,Eaton, S.,Dellos-Nolan, S.,Baldridge, I.,Srivastava, P.,Kennedy-Mendez, A.,Pillar, C.M.,Hufnagel, D.A.,Kebriaei, R.,Bell, C.E.,Wozniak, D.J.,Yalowich, J.C.,Mitton-Fry, M.J.; In vitro and in vivo activity of OSUAB-0284, a preclinical candidate for Staphylococcus aureus infection; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.75 Å)