36UJ

Crystal Structure of IDH1 (R132H) in complex with covalent inhibitor LY3410738

This is a non-PDB format compatible entry.

Summary for 36UJ

• Entry DOI: 10.2210/pdb36uj/pdb
• Related: 36TD 36UI
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, CHLORIDE ION, 7-{[(1S)-1-{4-[(1S)-2-cyclopropyl-1-(4-propanoylpiperazin-1-yl)ethyl]phenyl}ethyl]amino}-1-ethyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-one, ... (5 entities in total)
• Functional Keywords: idh1, idh2, covalent, inhibitor, ly3410738, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 96945.69

Authors

Antonysamy, S.S. (deposition date: 2026-07-01, release date: 2026-07-22)

• Primary citation: Antonysamy, S.S.; LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.442 Å)