36TD

Crystal Structure of IDH2 (R172K) in complex with covalent inhibitor LY3410738

This is a non-PDB format compatible entry.

Summary for 36TD

• Entry DOI: 10.2210/pdb36td/pdb
• Descriptor: Isocitrate dehydrogenase [NADP], mitochondrial, 7-{[(1S)-1-{4-[(1S)-2-cyclopropyl-1-(4-propanoylpiperazin-1-yl)ethyl]phenyl}ethyl]amino}-1-ethyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: idh1, idh2, covalent, inhibitor, ly3410738, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 105751.27

Authors

Antonysamy, S.S. (deposition date: 2026-06-30, release date: 2026-07-22)

• Primary citation: Antonysamy, S.S.; LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)