36OU

Room-temperature multiconformer model of PSD-95 PDZ3-CRIPT

Summary for 36OU

• Entry DOI: 10.2210/pdb36ou/pdb
• Descriptor: Disks large homolog 4, Cysteine-rich PDZ-binding protein (3 entities in total)
• Functional Keywords: third pdz domain of psd-95 bound to cript, peptide binding protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 13807.28

Authors

Wang, H.K.,Hekstra, D.R.,White, K.I. (deposition date: 2026-06-24, release date: 2026-11-04)

Primary citation

Wang, H.K.,Greisman, J.B.,Dalton, K.M.,Hewitt, R.A.,White, K.I.,Hekstra, D.R.
Symmetry Breaking under Vectorial Perturbations in Macromolecular X-ray Crystallography.
Biorxiv, 2026

PubMed Abstract: Proteins are molecular machines whose dynamics govern their function. Using time-resolved crystallography, the basis of protein mechanics can be uncovered by physical perturbation on protein crystals. Perturbations are often vector fields that, in crystals, break symmetry. Lacking existing tools for analyzing symmetry breaking, we built open-source software to do so. We applied this method to three time-resolved crystallography experiments and analyzed the effect of vectorial perturbations on macromolecular crystal structure. We demonstrate that our method can handle symmetry reduction in all 65 Sohncke space groups.

PubMed: 42856210
DOI: 10.64898/2026.09.28.753211

Experimental method

X-RAY DIFFRACTION (1.35 Å)