36OQ

Structure of rabbit actin bound to a truncated Mycalolide B analogue containing an expanded cyclohexane moiety

This is a non-PDB format compatible entry.

Summary for 36OQ

• Entry DOI: 10.2210/pdb36oq/pdb
• Related: 6w7v
• Descriptor: Actin, alpha skeletal muscle, 1,2-ETHANEDIOL, CALCIUM ION, ... (7 entities in total)
• Functional Keywords: actin monomer, cytoskeleton, actin-small molecule complex, antimetastatic agent, contractile protein
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 42870.75

Authors

Alexander, C.K.,Trofimova, D.,Allingham, J.S. (deposition date: 2026-06-24, release date: 2026-08-19)

• Primary citation: Trofimova, D.,Alexander, C.K.,Jiang, Y.,Veeranna, K.D.,Craig, A.W.,Evans, A.P.,Allingham, J.S.; Actin-binding is not enough: solvent-facing substituents maximize cellular efficacy of actin-disrupting macrolide analogues; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.72 Å)