36KW

Tri-complex of Compound 42, KRas G12D, and CypA

This is a non-PDB format compatible entry.

Summary for 36KW

• Entry DOI: 10.2210/pdb36kw/pdb
• Descriptor: Isoform 2B of GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (8 entities in total)
• Functional Keywords: inhibitor, complex, small gtpase, cancer, tri-complex, signaling protein-inhibitor complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 78575.30

Authors

Tomlinson, A.C.A.,Yano, J.K. (deposition date: 2026-06-16, release date: 2026-11-11)

• Primary citation: Burnett, G.L.,Weller, C.,Jiang, L.,Tye, M.A.,Tomlinson, A.C.A.,Shivakumar, D.M.,Xiao, G.,Liu, Y.,Gliedt, M.J.,Edwards, A.V.,Aggen, J.B.,Lanning, S.,Marquez, A.,Steele, S.L.,Flagella, M.,Wang, Z.,Singh, M.,Wang, Z.,Jiang, J.,Smith, J.A.M.,Wildes, D.,Knox, J.E.,Koltun, E.S.,Gill, A.L.; Discovery of Zoldonrasib (RMC-9805), a Potent and Orally Bioavailable RAS(ON) G12D-Selective, Covalent, Tri-Complex Inhibitor for the Treatment of Patients with RAS G12D-Addicted Cancers; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c02020

Experimental method

X-RAY DIFFRACTION (1.11 Å)