36JM

Tri-complex of Compound 1, KRas Q61H, and CypA

This is a non-PDB format compatible entry.

Summary for 36JM

• Entry DOI: 10.2210/pdb36jm/pdb
• Descriptor: Isoform 2B of GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (7 entities in total)
• Functional Keywords: inhibitor, complex, small gtpase, cancer, tri-complex, signaling protein-inhibitor complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 77928.89

Authors

Tomlinson, A.C.A.,Yano, J.K. (deposition date: 2026-06-14, release date: 2026-11-11)

• Primary citation: Thompson, S.K.,Yang, Y.C.,Lopez Quinones, A.J.,Chang, S.,McKinley, J.L.,Tomlinson, A.C.A.,Tooley, A.S.,Wei, X.,Flagella, M.,Buckl, A.,Gliedt, M.J.,Yin, J.,Liu, Y.,Chen, A.,Montgomery, D.C.,Marquez, A.,Eilerts, D.F.,Probst, J.,McNamara, A.,Shivakumar, D.M.,Wang, Z.,Knox, J.E.,Wang, Z.,Gill, A.L.,Koltun, E.S.; Discovery of RMC-0708, an Oral, Bis-Macrocyclic, RAS(ON) Q61H-Selective, Noncovalent, Tri-Complex Inhibitor; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c02019

Experimental method

X-RAY DIFFRACTION (1.4 Å)