366D
1.3 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/6-BROMO-9-AMINO-DACA COMPLEX
Summary for 366D
Entry DOI | 10.2210/pdb366d/pdb |
Descriptor | DNA (5'-D(*CP*GP*(BRU)P*AP*CP*G)-3'), 6-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total) |
Functional Keywords | dna, drug intercalation, major groove binding |
Total number of polymer chains | 1 |
Total formula weight | 2652.67 |
Authors | Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Cardin, C.J. (deposition date: 1997-12-19, release date: 1999-04-06, Last modification date: 2024-02-21) |
Primary citation | Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.,Cardin, C.J. Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution. J.Med.Chem., 42:536-540, 1999 Cited by PubMed: 10052960DOI: 10.1021/jm980479u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
Download full validation report