32XB
Cupin protein GloB from Pseudomonas aeruginosa
Summary for 32XB
| Entry DOI | 10.2210/pdb32xb/pdb |
| Descriptor | ChrR-like cupin domain-containing protein, MAGNESIUM ION, POTASSIUM ION, ... (4 entities in total) |
| Functional Keywords | pseudomonas aeruginosa, biosynthetic gene cluster, cupin domain, unknown function |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 4 |
| Total formula weight | 54097.71 |
| Authors | Contreras-Martel, C.,Duarte, K.,Macheboeuf, P. (deposition date: 2026-07-29, release date: 2026-11-04) |
| Primary citation | Contreras-Martel, C.,Duarte, K.,Macheboeuf, P. Structure of the cupin protein GloB from Pseudomonas aeruginosa at 1.48 angstrom resolution. Acta Crystallogr.,Sect.F, 2026 Cited by PubMed Abstract: Pseudomonas aeruginosa is an opportunistic pathogen that causes severe infections in vulnerable patients. Highly virulent strains associated with hemorrhagic pneumonia harbor the glo nonribosomal peptide synthetase (NRPS) operon, the metabolic product of which remains unknown. The glo operon shares similarity with similar clusters from related bacteria, enabling the functional assignment of several glo genes, including gloB, which encodes a cupin-domain protein predicted to catalyze a metal-dependent step in the pathway. Here, we present the crystal structure of the GloB cupin domain from P. aeruginosa. The structure provides insight into part of the biosynthesis of an uncharacterized secondary metabolite and offers a foundation for understanding its potential contribution to bacterial pathogenicity. PubMed: 42929186DOI: 10.1107/S2053230X26010514 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
Download full validation report
