32VC
Structure of the RND transporter MexB in complex with the reference inhibitor phenylalanine-arginine beta-naphthylamide.
Summary for 32VC
| Entry DOI | 10.2210/pdb32vc/pdb |
| EMDB information | 59194 |
| Descriptor | Multidrug resistance protein MexB, N2-(L-PHENYLALANYL)-N1-(NAPHTHALENYL)-L-ARIGNINAMIDE (3 entities in total) |
| Functional Keywords | rnd transporter gram-negative bacteria membrane protein inhibitor pseudomonas aeruginosa, antimicrobial protein |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 3 |
| Total formula weight | 343117.26 |
| Authors | |
| Primary citation | Wehbi, H.,Olivier, E.,Cece, Q.,Megret, M.,Sebastien, M.,Aissaoui, N.,Llanes, C.,Phan, G.,Broutin, I. Revisit of the admitted control RND efflux pumps' inhibitor PA beta N: use limitations, and structural revelation in complex with MexB. Front Pharmacol, 17:1906963-1906963, 2026 Cited by PubMed Abstract: To bypass the health problem of antibiotic resistance in Gram-negative bacteria, a tempting approach is to use efflux pump inhibitors (EPI) to block the transporters before they expel antibiotics from the cell. One well-known EPI is the phenylalanine-arginine beta-naphthylamide (PAβN). Although it is described as toxic and therefore unsuitable for clinical use, it is highly effective and is commonly used as EPI reference compound in drug development. Nevertheless, the lack of toxicity on several cellular strains in our hands required us to revisit this known RND inhibitor, to redefine its limits. PubMed: 42974023DOI: 10.3389/fphar.2026.1906963 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.38 Å) |
Structure validation
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