32SA

Crystal structure of YTHDF2 in complex with compound 5 (ZA780)

This is a non-PDB format compatible entry.

Summary for 32SA

• Entry DOI: 10.2210/pdb32sa/pdb
• Descriptor: YTH domain-containing family protein 2, GLYCEROL, 6-cyclopropyl-2,7-dihydropyrazolo[3,4-b]pyridin-4-one, ... (6 entities in total)
• Functional Keywords: inhibitor, m6a reader, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 39886.06

Authors

Nai, F.,Zalesak, F.,Caflisch, A. (deposition date: 2026-07-22, release date: 2026-11-11)

• Primary citation: Errani, F.,Nai, F.,Bochenkova, E.,Herok, M.,Invernizzi, A.,Bedi, R.K.,Li, Y.,Zalesak, F.,Caflisch, A.; Structure-Based Design of Potent Pan-YTHDF Ligands; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c02977

Experimental method

X-RAY DIFFRACTION (1.52 Å)