32MP

Solution structure of a chimeric peptide derived from trpzip2 and the disulfide loop of the PilA protein from P. aeruginosa

Summary for 32MP

• Entry DOI: 10.2210/pdb32mp/pdb
• NMR Information: BMRB: 35075
• Descriptor: Fimbrial protein (1 entity in total)
• Functional Keywords: structure from cyana 3.98.15, immune system
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 3164.46

Authors

Sette, M. (deposition date: 2026-07-16, release date: 2026-08-19, Last modification date: 2026-09-02)

Primary citation

Trappetti, C.,van Ingen, H.,Falconi, M.,Romeo, A.,Sancamillo, G.,Caprini, M.,Oggioni, M.R.,Sette, M.
Structured peptides as vaccine antigens against infections.
Front Immunol, 17:1908831-1908831, 2026

PubMed Abstract: The onset of a new infection by a pathogen requires a rapid and prompt response from the body. Here, we present a simple and effective strategy to stimulate antibody production by grafting immunogenic peptides onto a beta-strand peptide scaffold. Analysis of the method using a known immunogenic region, the disulfide loop of the PilA protein of the pilus, shows that the molecule folds properly in solution and, upon vaccination of mice, provides significant protection against intravenous challenge with the PAK strain.

PubMed: 42630162
DOI: 10.3389/fimmu.2026.1908831

Experimental method

SOLUTION NMR