32HC

PARP9 Macro Domain 2 P347G mutant in complex with ADPr

Summary for 32HC

• Entry DOI: 10.2210/pdb32hc/pdb
• Descriptor: Protein mono-ADP-ribosyltransferase PARP9, ADENOSINE-5-DIPHOSPHORIBOSE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (4 entities in total)
• Functional Keywords: parp9, adpr, macro domain, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23311.43

Authors

Chikunova, A.,Fourkiotis, K.N.,Spyroulias, A.G.,Perrakis, A. (deposition date: 2026-07-09, release date: 2026-08-26)

• Primary citation: Fourkiotis, K.N.,Sideras-Bisdekis, C.,Tsika, C.A.,Fish, A.,Kravvariti, P.K.,Tsatsouli, S.A.,Perrakis, A.,Chikunova, A.,Spyroulias, A.G.; So different, yet so similar: the paradigm of PARP9 macro domain paralogs; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)